|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||30519 Da|
|Dilution||IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:2000),|
|Other Names||DCK, Deoxynucleoside kinase, Deoxycytidine kinase|
|Target/Specificity||Human DCK / Deoxycytidine kinase|
|Reconstitution & Storage||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.|
|Precautions||DCK / Deoxycytidine kinase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.|
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Provided below are standard protocols that you may find useful for product applications.
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Chottiner E.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1531-1535(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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