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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   ICOS Antibody   

ICOS Antibody

Rabbit Polyclonal Antibody

     
  • IHC - ICOS Antibody ALS17079
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - ICOS Antibody ALS17079
    Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - ICOS Antibody ALS17079
    Immunofluorescence analysis of MCF7 cell using ICOS antibody. Blue: DAPI for nuclear staining.
  • WB - ICOS Antibody ALS17079
    Western blot analysis of extracts of various cell lines, using ICOS antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q9Y6W8
Other Accession 29851
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 22625 Da
Dilution IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 29851
Other Names ICOS, AILIM, CD278, CVID1, Inducible costimulator, Inducible T-cell co-stimulator, CD278 antigen, Inducible T-cell costimulator
Target/Specificity Human ICOS
Reconstitution & Storage PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
PrecautionsICOS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICOS
Synonyms AILIM
Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Volume 50 µl
Research Areas
Citations (0)

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Background

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

References

Hutloff A.,et al.Nature 397:263-266(1999).
Tezuka K.,et al.Biochem. Biophys. Res. Commun. 276:335-345(2000).
Aicher A.,et al.J. Immunol. 164:4689-4696(2000).
Ling V.,et al.Genomics 78:155-168(2001).
Haaning Andersen A.D.,et al.Tissue Antigens 61:276-285(2003).

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$ 395.00
Cat# ALS17079
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