|Application ||WB, IHC-P, IF, ICC, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||59226 Da|
|Dilution||ICC (2.5 µg/ml), IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),|
|Other Names||OASL, 2-5-OAS-related protein, 2-5-OAS-RP, p59-OASL, p59OASL, TR-interacting protein 14, TRIP-14, TRIP14, OASLd, p59 OASL|
|Target/Specificity||OASL antibody is human, mouse and rat reactive.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||OASL Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.|
|Cellular Location||Isoform p56: Nucleus, nucleolus. Cytoplasm.|
|Tissue Location||Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis|
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Provided below are standard protocols that you may find useful for product applications.
Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Hartmann R.,et al.Nucleic Acids Res. 26:4121-4127(1998).
Rebouillat D.,et al.Eur. J. Biochem. 257:319-330(1998).
Guo X.,et al.Int. J. Biochem. Cell Biol. 44:1133-1138(2012).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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