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FBN1 / Fibrillin 1 Antibody

Mouse Monoclonal Antibody

     
  • IHC - FBN1 / Fibrillin 1 Antibody ALS17098
    Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, E, IP
Primary Accession P35555
Other Accession 2200
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 312237 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 2200
Other Names FBN1, ACMICD, Fibrillin 1, Fibrillin-1, FBN, ECTOL1, GPHYSD2, MASS, MFS1, OCTD, SSKS, WMS2, Fibrillin 1 (Marfan syndrome), Fibrillin 15, SGS, WMS
Target/Specificity Recognizes human Fibrillin-1. Epitope mapping studies identify the binding site of this antibody to amino-terminal end of the molecule, between amino acid residues 45 and 450. The antibody is reactive with human, chicken, and bovine Fibrillin-1.
Reconstitution & Storage 0.02 M phosphate buffer, pH 7.6, 0.25 M sodium chloride, 0.1% sodium azide. +4°C. Store undiluted.
PrecautionsFBN1 / Fibrillin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBN1
Synonyms FBN
Function Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
Cellular Location Secreted, extracellular space, extracellular matrix
Volume 50 µl
Research Areas
Citations (0)

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Background

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

References

Pereira L.V.,et al.Hum. Mol. Genet. 2:961-968(1993).
Uyeda T.,et al.J. Hum. Genet. 49:404-407(2004).
Rieder M.J.,et al.Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS17098
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