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GRIN2A / NMDAR2A / NR2A Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q12879 |
| Other Accession | 2903 |
| Reactivity | Mouse, Rat, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 165283 Da |
| Dilution | IHC-P (1:100), WB (1:1000), |
| Gene ID | 2903 |
|---|---|
| Other Names | GRIN2A, EPND, HNR2A, GluN2A, GluR epsilon 1, NMDA receptor 2A, NMDAR2A, NR2A, NMDA receptor subtype 2A |
| Target/Specificity | Specific for the ~180k NR2A subunit of the NMDA receptor |
| Reconstitution & Storage | 10 mM HEPES, pH 7.5, 150 mM sodium chloride, 100 ug per ml BSA, 50% glycerol. Long term: -20°C; Short term: -20°C |
| Precautions | GRIN2A / NMDAR2A / NR2A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRIN2A |
|---|---|
| Synonyms | NMDAR2A |
| Function | Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long- term synaptic potentiation, and learning (By similarity). |
| Cellular Location | Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q00959}. Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250|UniProtKB:P35436} Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436} |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
References
Foldes R.L.,et al.Biochim. Biophys. Acta 1223:155-159(1994).
Hess S.D.,et al.J. Pharmacol. Exp. Ther. 278:808-816(1996).
Martin J.,et al.Nature 432:988-994(2004).
Endele S.,et al.Nat. Genet. 42:1021-1026(2010).
Wei X.,et al.Nat. Genet. 43:442-446(2011).
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