DNAJC13 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O75165 |
Other Accession | 23317 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 254415 Da |
Dilution | IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
Gene ID | 23317 |
---|---|
Other Names | DNAJC13, KIAA0678, RME8, RME-8 |
Target/Specificity | DNAJC13 antibody is human and mouse reactive. At least two siforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is predicted to not cross-react with other DNAJC family members. |
Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | DNAJC13 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DNAJC13 |
---|---|
Synonyms | KIAA0678, RME8 |
Function | Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates the dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). |
Cellular Location | Early endosome. Early endosome membrane; Peripheral membrane protein. Endosome membrane |
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Background
Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).
References
Girard M.,et al.J. Biol. Chem. 280:40135-40143(2005).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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