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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TXNIP Antibody (Internal)   

TXNIP Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - TXNIP Antibody (Internal) ALS17113
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - TXNIP Antibody (Internal) ALS17113
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H3M7
Other Accession 10628
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 43661 Da
Dilution IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml),
Additional Information
Gene ID 10628
Other Names TXNIP, HHCPA78, THIF, VDUP1, Thioredoxin binding protein 2, Thioredoxin-binding protein 2, EST01027
Target/Specificity TXNIP antibody is human, mouse and rat reactive.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTXNIP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNIP
Synonyms VDUP1
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

References

Chen K.-S.,et al.Biochim. Biophys. Acta 1219:26-32(1994).
Liyanage N.P.M.,et al.Exp. Eye Res. 85:270-279(2007).
Toyama S.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 395.00
Cat# ALS17113
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