PIK3R4 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q99570 |
Other Accession | 30849 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 153103 Da |
Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
Gene ID | 30849 |
---|---|
Other Names | PIK3R4, Adaptor protein p150, p150, PI3-kinase p150 subunit, VPS15 |
Target/Specificity | PIK3R4 antibody is human, mouse and rat reactive. |
Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | PIK3R4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PIK3R4 |
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Synonyms | VPS15 {ECO:0000303|PubMed:23878393} |
Function | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). |
Cellular Location | Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity) {ECO:0000250|UniProtKB:Q8VD65, ECO:0000305} |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.
References
Panaretou C.,et al.J. Biol. Chem. 272:2477-2485(1997).
Stein M.P.,et al.Traffic 4:754-771(2003).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
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