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PIK3R4 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - PIK3R4 Antibody (C-Terminus) ALS17114
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - PIK3R4 Antibody (C-Terminus) ALS17114
    Immunofluorescence of PIK3R4 in human tonsil tissue with PIK3R4 antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q99570
Other Accession 30849
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 153103 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 30849
Other Names PIK3R4, Adaptor protein p150, p150, PI3-kinase p150 subunit, VPS15
Target/Specificity PIK3R4 antibody is human, mouse and rat reactive.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsPIK3R4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIK3R4
Synonyms VPS15 {ECO:0000303|PubMed:23878393}
Function Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Cellular Location Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q8VD65, ECO:0000305}
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Background

Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.

References

Panaretou C.,et al.J. Biol. Chem. 272:2477-2485(1997).
Stein M.P.,et al.Traffic 4:754-771(2003).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).

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$ 395.00
Cat# ALS17114
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