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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NLGN2 / Neuroligin 2 Antibody (C-Terminus)   

NLGN2 / Neuroligin 2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - NLGN2 / Neuroligin 2 Antibody (C-Terminus) ALS17116
    Immunohistochemistry of NLGN2 in mouse brain tissue with NLGN2 antibody at 5 ug/ml.
  • IHC - NLGN2 / Neuroligin 2 Antibody (C-Terminus) ALS17116
    Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - NLGN2 / Neuroligin 2 Antibody (C-Terminus) ALS17116
    Immunofluorescence of NLGN2 in mouse brain tissue with NLGN2 antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8NFZ4
Other Accession 57555
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 90820 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 57555
Other Names NLGN2, KIAA1366, Neuroligin 2, Neuroligin-2
Target/Specificity NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsNLGN2 / Neuroligin 2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLGN2
Synonyms KIAA1366
Function Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity).
Tissue Location Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
Research Areas
Citations (0)

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Background

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).

References

Jamain S.,et al.Nat. Genet. 34:27-29(2003).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Irie M.,et al.Science 277:1511-1515(1997).
Suckow A.T.,et al.Endocrinology 149:6006-6017(2008).
Bottos A.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009).

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$ 395.00
Cat# ALS17116
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