|Application ||WB, IHC-P, IF, E|
|Calculated MW||67258 Da|
|Dilution||IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),|
|Other Names||DTX4, Deltex homolog 4 (Drosophila), Deltex4, KIAA0937, RNF155, Protein deltex-4, RING finger protein 155, Deltex 4 homolog, Deltex 4 homolog (Drosophila)|
|Target/Specificity||DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||DTX4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.|
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Provided below are standard protocols that you may find useful for product applications.
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Nagase T.,et al.DNA Res. 6:63-70(1999).
Storck S.,et al.Mol. Cell. Biol. 25:1437-1445(2005).
Cui J.,et al.Nat. Immunol. 13:387-395(2012).
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