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DTX4 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9Y2E6 |
| Other Accession | 23220 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67258 Da |
| Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
| Gene ID | 23220 |
|---|---|
| Other Names | DTX4, Deltex homolog 4 (Drosophila), Deltex4, KIAA0937, RNF155, Protein deltex-4, RING finger protein 155, Deltex 4 homolog, Deltex 4 homolog (Drosophila) |
| Target/Specificity | DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | DTX4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DTX4 |
|---|---|
| Synonyms | KIAA0937, RNF155 |
| Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
References
Nagase T.,et al.DNA Res. 6:63-70(1999).
Storck S.,et al.Mol. Cell. Biol. 25:1437-1445(2005).
Cui J.,et al.Nat. Immunol. 13:387-395(2012).
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