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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GABARAPL2 / ATG8 Antibody (C-Terminus)   

GABARAPL2 / ATG8 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GABARAPL2 / ATG8 Antibody (C-Terminus) ALS17123
    Immunohistochemistry of GABARAPL2 in rat brain tissue with GABARAPL2 antibody at 5 ug/mL.
  • IHC - GABARAPL2 / ATG8 Antibody (C-Terminus) ALS17123
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - GABARAPL2 / ATG8 Antibody (C-Terminus) ALS17123
    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - GABARAPL2 / ATG8 Antibody (C-Terminus) ALS17123
    Immunofluorescence of GABARAPL2 in rat brain tissue with GABARAPL2 antibody at 20 ug/mL.
  • WB - GABARAPL2 / ATG8 Antibody (C-Terminus) ALS17123
    Western blot analysis of GABARAPL2 in human brain tissue lysate with GABARAPL2 antibody at (A) 1...
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P60520
Other Accession 11345
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 13667 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 11345
Other Names GABARAPL2, ATG8, ATG8C, GEF2, FLC3A, GATE-16, GATE16, GEF-2
Target/Specificity GABARAPL2 antibody is human, mouse and rat reactive. Multiple isoforms of GABARAPL2 are known to exist.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGABARAPL2 / ATG8 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABARAPL2
Synonyms FLC3A, GEF2
Function Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Cellular Location Golgi apparatus. Cytoplasmic vesicle, autophagosome
Tissue Location Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle Expressed at very low levels in lung, thymus and small intestine
Research Areas
Citations (0)

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Background

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

References

Okazaki N.,et al.Brain Res. Mol. Brain Res. 85:1-12(2000).
Xin Y.,et al.Genomics 74:408-413(2001).
Storch S.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Song H.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS17123
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