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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SNCA / Alpha-Synuclein Antibody (C-Terminus)   

SNCA / Alpha-Synuclein Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SNCA / Alpha-Synuclein Antibody (C-Terminus) ALS17124
    Immunohistochemistry of SNCA in rat brain tissue with SNCA antibody at 5 ug/ml.
  • IHC - SNCA / Alpha-Synuclein Antibody (C-Terminus) ALS17124
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - SNCA / Alpha-Synuclein Antibody (C-Terminus) ALS17124
    Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - SNCA / Alpha-Synuclein Antibody (C-Terminus) ALS17124
    Immunofluorescence of SNCA in rat brain tissue with SNCA antibody at 20 ug/ml.
  • WB - SNCA / Alpha-Synuclein Antibody (C-Terminus) ALS17124
    Western blot analysis of SNCA in mouse cerebellum tissue lysate with SNCA antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P37840
Other Accession 6622
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 14460 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 6622
Other Names SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1
Target/Specificity SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSNCA / Alpha-Synuclein Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNCA
Synonyms NACP, PARK1
Function May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Cellular Location Cytoplasm, cytosol Membrane. Nucleus. Cell junction, synapse. Secreted. Note=Membrane-bound in dopaminergic neurons.
Tissue Location Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals
Research Areas
Citations (0)

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Background

May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

References

Ueda K.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993).
Campion D.,et al.Genomics 26:254-257(1995).
Ueda K.,et al.Biochem. Biophys. Res. Commun. 205:1366-1372(1994).
Xia Y.,et al.Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
Touchman J.W.,et al.Genome Res. 11:78-86(2001).

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$ 395.00
Cat# ALS17124
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