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PLEKHA8 Antibody (aa122-400)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96JA3 |
| Other Accession | 84725 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58261 Da |
| Dilution | ELISA (1:20000 - 1:80000), IHC-P (10 µg/ml), WB (1:1000 - 1:2000), |
| Gene ID | 84725 |
|---|---|
| Other Names | PLEKHA8, FAPP2, FAPP-2, HFAPP2 |
| Target/Specificity | Human PLEKHA8. |
| Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year. |
| Precautions | PLEKHA8 Antibody (aa122-400) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLEKHA8 |
|---|---|
| Synonyms | FAPP2 |
| Function | Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4- phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites |
| Tissue Location | Expressed in kidney cell lines. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
References
Dowler S.J.,et al.Biochem. J. 351:19-31(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Scanlan M.J.,et al.Cancer Immun. 1:4-4(2001).
Godi A.,et al.Nat. Cell Biol. 6:393-404(2004).
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