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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLEKHA8 Antibody (aa122-400)   

PLEKHA8 Antibody (aa122-400)

Rabbit Polyclonal Antibody

     
  • IHC-P - PLEKHA8 Antibody (aa122-400) ALS17129
    Human Uterus, Endometrium: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC-P - PLEKHA8 Antibody (aa122-400) ALS17129
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - PLEKHA8 Antibody (aa122-400) ALS17129
    western blot analysis of fetal liver,fetal heart and fetal kidney lysate with anti-plekha8 antibody
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96JA3
Other Accession 84725
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 58261 Da
Dilution ELISA (1:20000 - 1:80000), IHC-P (10 µg/ml), WB (1:1000 - 1:2000),
Additional Information
Gene ID 84725
Other Names PLEKHA8, FAPP2, FAPP-2, HFAPP2
Target/Specificity Human PLEKHA8.
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.
PrecautionsPLEKHA8 Antibody (aa122-400) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLEKHA8
Synonyms FAPP2
Function Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Cellular Location Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites.
Tissue Location Expressed in kidney cell lines.
Volume 50 µl
Research Areas
Citations (0)

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Background

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

References

Dowler S.J.,et al.Biochem. J. 351:19-31(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Scanlan M.J.,et al.Cancer Immun. 1:4-4(2001).
Godi A.,et al.Nat. Cell Biol. 6:393-404(2004).

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$ 395.00
Cat# ALS17129
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