|Application ||WB, IHC-P, IF, Flo|
|Calculated MW||67209 Da|
|Dilution||Flo (1:100), IF (1:100), IHC-P (5 µg/ml), WB (1:2000),|
|Other Names||GBP2, GBP-2, HuGBP-2, Guanylate binding protein 2, GTP-binding protein 2|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.|
|Precautions||GBP2 Antibody (clone 5C8) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid- anchor. Note=GBP2-GBP5 dimers localize to the Golgi apparatus.|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
Cheng Y.-S.E.,et al.Mol. Cell. Biol. 11:4717-4725(1991).
Schwemmle M.,et al.Submitted (SEP-1991) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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