|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||305011 Da|
|Dilution||IHC-P (10 µg/ml), WB (1 - 2 µg/ml), WB (1 - 2 µg/ml),|
|Other Names||TENM1, Teneurin-1, TNM, ODZ1, ODZ3, TEN-M1, TNM1|
|Target/Specificity||TENM1 antibody is human, mouse and rat reactive. TENM1 antibody is predicted to not cross-react with other members of the TENM family.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TNM / Teneurin-1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).|
|Cellular Location||Cell membrane; Single-pass membrane protein Teneurin C-terminal-associated peptide: Nucleus. Cytoplasm. Cell membrane. Note=Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity).|
|Tissue Location||Expressed in fetal brain.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).
Brandau O.,et al.Hum. Mol. Genet. 8:2407-2413(1999).
Ross M.T.,et al.Nature 434:325-337(2005).
Minet A.D.,et al.J. Cell Sci. 112:2019-2032(1999).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Sjoeblom T.,et al.Science 314:268-274(2006).
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