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LTA4H / LTA4 Antibody (clone 8F4)

Mouse Monoclonal Antibody

     
  • IHC-P - LTA4H / LTA4 Antibody (clone 8F4) ALS17143
    Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • WB - LTA4H / LTA4 Antibody (clone 8F4) ALS17143
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LTA4H...
    detail
  • WB - LTA4H / LTA4 Antibody (clone 8F4) ALS17143
    Western blot of extracts (35 ug) from 9 different cell lines by using anti-LTA4H monoclonal...
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P09960
Other Accession 4048
Reactivity Human, Rat, Dog
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 8F4
Calculated MW 69285 Da
Dilution IHC-P (1:50), WB (1:2000),
Additional Information
Gene ID 4048
Other Names LTA4H, Leukotriene A(4) hydrolase, Leukotriene A4 hydrolase, Leukotriene A-4 hydrolase, LTA-4 hydrolase, LTA4
Target/Specificity Human LTA4H / LTA4
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsLTA4H / LTA4 Antibody (clone 8F4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LTA4H
Synonyms LTA4
Function Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti- inflammatory and pro-resolving actions (PubMed:21206090).
Cellular Location Cytoplasm.
Tissue Location Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

References

Minami M.,et al.J. Biol. Chem. 262:13873-13876(1987).
Funk C.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6677-6681(1987).
Mancini J.A.,et al.Eur. J. Biochem. 231:65-71(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS17143
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