|Application ||WB, IHC-P, IF, Flo|
|Calculated MW||84331 Da|
|Dilution||Flo (1:100), IF (1:100), IHC-P (1:150), WB (1:500 - 1:1000),|
|Other Names||FOLH1, Folate hydrolase 1, GCPII, Glutamate carboxypeptidase II, Folate hydrolase, GCP2, NAALAD1, NAALAdase, NAALADase I, PSM, FGCP, FOLH, Glutamate carboxylase II, Glutamate carboxypeptidase 2, MGCP, PSMA|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.|
|Precautions||FOLH1 / PSMA Antibody (clone 3H5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FOLH, NAALAD1, PSM, PSMA|
|Function||Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer|
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Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
Israeli R.S.,et al.Cancer Res. 53:227-230(1993).
Su S.L.,et al.Cancer Res. 55:1441-1443(1995).
O'Keefe D.S.,et al.Biochim. Biophys. Acta 1443:113-127(1998).
Luthi-Carter R.,et al.J. Pharmacol. Exp. Ther. 286:1020-1025(1998).
Pangalos M.N.,et al.J. Biol. Chem. 274:8470-8483(1999).
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