|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||47518 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||GOT2, FABP-1, MitAAT, Transaminase A, FABPpm, Fatty acid-binding protein, KAT4, KATIV, Kynurenine aminotransferase IV, MAspAT|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.|
|Precautions||GOT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.|
|Cellular Location||Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Pol S.,et al.Biochem. Biophys. Res. Commun. 157:1309-1315(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Martin J.,et al.Nature 432:988-994(2004).
Martini F.,et al.Biochim. Biophys. Acta 832:46-51(1985).
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