|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||18012 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||PPIA, Cyclophilin, Cyclosporin A-binding protein, Cyclophilin A, PPIase A, Rotamase A, CYPH, T cell cyclophilin|
|Target/Specificity||Human PPIA / Cyclophilin A|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.|
|Precautions||PPIA / Cyclophilin A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|
|Cellular Location||Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation|
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Provided below are standard protocols that you may find useful for product applications.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Haendler B.,et al.EMBO J. 6:947-950(1987).
Haendler B.,et al.Eur. J. Biochem. 190:477-482(1990).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
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