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MAOB / Monoamine Oxidase B Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P27338 |
| Other Accession | 4129 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 58763 Da |
| Dilution | IHC-P (10 µg/ml), |
| Gene ID | 4129 |
|---|---|
| Other Names | MAOB, Adrenalin oxidase, MAO, brain, MAO-B, Monoamine oxidase type B, MAO, platelet, Tyramine oxidase, Monoamine oxidase B |
| Target/Specificity | Human MAOB / Monoamine Oxidase B |
| Reconstitution & Storage | PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MAOB / Monoamine Oxidase B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAOB (HGNC:6834) |
|---|---|
| Function | Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). |
| Cellular Location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
References
Grimsby J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:3637-3641(1991).
Bach A.W.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4934-4938(1988).
Chen K.,et al.J. Neurochem. 61:187-190(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
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