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AOX1 / Aldehyde Oxidase Antibody

Rabbit Polyclonal Antibody

     
  • IHC-P - AOX1 / Aldehyde Oxidase Antibody ALS17160
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • IHC-P - AOX1 / Aldehyde Oxidase Antibody ALS17160
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q06278
Other Accession 316
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 147918 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 316
Other Names AOX1, AO, Aldehyde oxidase 1, AOH1, Aldehyde oxidase
Target/Specificity Human AOX1 / Aldehyde Oxidase
Reconstitution & Storage PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAOX1 / Aldehyde Oxidase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AOX1 (HGNC:553)
Synonyms AO
Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
Cellular Location Cytoplasm
Tissue Location Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
Research Areas
Citations (0)
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Background

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.

References

Wright R.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993).
Wright R.M.,et al.Redox Rep. 3:135-144(1997).
Ichida K.,et al.Biochem. Biophys. Res. Commun. 282:1194-1200(2001).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS17160
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