|Application ||WB, IHC-P, E|
|Calculated MW||79995 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||CAPN2, Calpain 2, large subunit, Calpain ii, Calpain, large polypeptide L2, Calpain-2 catalytic subunit, Calpain 2, Calpain large polypeptide L2, Calpain-2 large subunit, CANP 2, Calpain M-type, CANP2, CANPL2, CANPml, M-type calpain, M-calpain, MCANP ...|
|Target/Specificity||Human CAPN2 / Calpain 2 / M-Calpain|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CAPN2 / Calpain 2 / M-Calpain Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508).
Imajoh S.,et al.Biochemistry 27:8122-8128(1988).
Ye Z.,et al.Biochem. Biophys. Res. Commun. 275:223-227(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Hata A.,et al.J. Biol. Chem. 264:6404-6411(1989).
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