DNTTIP1 / TDIF1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9H147 |
Other Accession | 116092 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 37013 Da |
Dilution | IHC-P (10 µg/ml), |
Gene ID | 116092 |
---|---|
Other Names | DNTTIP1, C20orf167, DJ447F3.4, Tdif1, TdT-interacting factor 1, TdT binding protein |
Target/Specificity | Human DNTTIP1 / TDIF1. |
Reconstitution & Storage | PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | DNTTIP1 / TDIF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DNTTIP1 |
---|---|
Synonyms | C20orf167, TDIF1 |
Function | Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. |
Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Shown to enhance TdT activity, in vitro. Also acts as a transcriptional regulator, binding to the consensus sequence 5'- GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription.
References
Yamashita N.,et al.Genes Cells 6:641-652(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
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