|Application ||WB, IHC-P, E|
|Calculated MW||37013 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||DNTTIP1, C20orf167, DJ447F3.4, Tdif1, TdT-interacting factor 1, TdT binding protein|
|Target/Specificity||Human DNTTIP1 / TDIF1.|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||DNTTIP1 / TDIF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'- GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.|
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Shown to enhance TdT activity, in vitro. Also acts as a transcriptional regulator, binding to the consensus sequence 5'- GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription.
Yamashita N.,et al.Genes Cells 6:641-652(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
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