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4E-BP2 / EIF4EBP2 Antibody

Rabbit Polyclonal Antibody

  • IHC-P - 4E-BP2 / EIF4EBP2 Antibody ALS17167
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC-P - 4E-BP2 / EIF4EBP2 Antibody ALS17167
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13542
Other Accession 1979
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 12939 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 1979
Other Names EIF4EBP2, 4E-BP2, 4EBP2, EIF4E-binding protein 2, PHASII
Target/Specificity Human 4E-BP2 / EIF4EBP2
Reconstitution & Storage PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Precautions4E-BP2 / EIF4EBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF4EBP2 (HGNC:3289)
Function Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).
Research Areas
Citations (0)

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Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.


Pause A.,et al.Nature 371:762-767(1994).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).

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$ 395.00
Cat# ALS17167
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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