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CYP3A4 / Cytochrome P450 3A4 Antibody

Rabbit Polyclonal Antibody

     
  • IHC-P - CYP3A4 / Cytochrome P450 3A4 Antibody ALS17176
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC-P - CYP3A4 / Cytochrome P450 3A4 Antibody ALS17176
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - CYP3A4 / Cytochrome P450 3A4 Antibody ALS17176
    Western blot analysis of extracts of Mouse liver, using CYP3A4 antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P08684
Other Accession 1576
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 57343 Da
Dilution IHC-P (5 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 1576
Other Names CYP3A4, Albendazole monooxygenase, Albendazole sulfoxidase, Cyp3a3, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, CP33, CP34, CYP3A, Cytochrome P450 NF-25, HLP, Nifedipine oxidase, Quinine 3-monooxygenase, NF-25, p450C3, Cytochrome P4 ...
Target/Specificity Human CYP3A4 / Cytochrome P450 3A4.
Reconstitution & Storage PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
PrecautionsCYP3A4 / Cytochrome P450 3A4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP3A4
Synonyms CYP3A3
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein
Tissue Location Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056) According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide.

References

Molowa D.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5311-5315(1986).
Gonzalez F.J.,et al.DNA 7:79-86(1988).
Beaune P.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:8064-8068(1986).
Spurr N.K.,et al.Hum. Genet. 81:171-174(1989).
Bork R.W.,et al.J. Biol. Chem. 264:910-919(1989).

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$ 395.00
Cat# ALS17176
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