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FZD9 / Frizzled 9 Antibody (aa542-591)

Rabbit Polyclonal Antibody

     
  • IHC-P - FZD9 / Frizzled 9 Antibody (aa542-591) ALS17180
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • IF - FZD9 / Frizzled 9 Antibody (aa542-591) ALS17180
    Immunofluorescence of A549 cells, using FZD9 Antibody.
    detail
  • WB - FZD9 / Frizzled 9 Antibody (aa542-591) ALS17180
    Western blot of extracts from HUVEC/COLO/COS cells, using FZD9 Antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O00144
Other Accession 8326
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 64466 Da
Dilution ELISA (1:20000), IF (1:100 - 1:500), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 8326
Other Names FZD9, CD349, Frizzled homolog 9, Fz-9, Frizzled family receptor 9, Frizzled-9, Frizzled 9, Fz9, HFz9, CD349 antigen, Frizzled homolog fzd3, FzE6
Target/Specificity FZD9 Antibody detects endogenous levels of total FZD9 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsFZD9 / Frizzled 9 Antibody (aa542-591) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD9
Synonyms FZD3
Function Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta- catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9R216}; Multi-pass membrane protein. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8}
Tissue Location Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850).
Volume 50 µl
Research Areas
Citations (0)
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Background

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

References

Wang Y.-K.,et al.Hum. Mol. Genet. 6:465-472(1997).
Hillier L.W.,et al.Nature 424:157-164(2003).
Tanaka S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998).

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Discontinued
Cat# ALS17180
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