PROC / Protein C Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | P04070 |
Other Accession | 5624 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 52071 Da |
Dilution | IHC-P (10 µg/ml), WB (1:500 - 1:3000), |
Gene ID | 5624 |
---|---|
Other Names | PROC, Anticoagulant protein C, Blood coagulation factor XIV, Autoprothrombin IIA, Protein C, PROC1, Vitamin K-dependent protein C, THPH3, THPH4 |
Target/Specificity | Human Protein C |
Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | PROC / Protein C Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PROC |
---|---|
Function | Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). |
Cellular Location | Secreted. Golgi apparatus Endoplasmic reticulum |
Tissue Location | Plasma; synthesized in the liver. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
References
Beckmann R.J.,et al.Nucleic Acids Res. 13:5233-5247(1985).
Foster D.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4673-4677(1985).
Plutzky J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:546-550(1986).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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