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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RIP1 / RALBP1 Antibody (clone OTI1H9)   

RIP1 / RALBP1 Antibody (clone OTI1H9)

Mouse Monoclonal Antibody

     
  • IHC-P - RIP1 / RALBP1 Antibody (clone OTI1H9) ALS17206
    Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - RIP1 / RALBP1 Antibody (clone OTI1H9) ALS17206
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RALBP1...
  • FC - RIP1 / RALBP1 Antibody (clone OTI1H9) ALS17206
    HEK293T cells transfected with either pCMV6-ENTRY RALBP1 (Red) or empty vector control plasmid...
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession Q15311
Other Accession 10928
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names OTI1H9
Calculated MW 76063 Da
Dilution Flo (1:100), IHC-P (10 µg/ml), WB (1:2000),
Additional Information
Gene ID 10928
Other Names RALBP1, 76 kDa Ral-interacting protein, DNP-SG ATPase, Ral-interacting protein 1, RalA-binding protein 1, RIP1, Rlip76 protein, RIP, RLIP1, RalA binding protein 1, RLIP76
Target/Specificity Human RALBP1
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsRIP1 / RALBP1 Antibody (clone OTI1H9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RALBP1
Synonyms RLIP1, RLIP76
Function Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Cellular Location Membrane; Peripheral membrane protein
Tissue Location Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes
Volume 50 µl
Research Areas
Citations (0)

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Background

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

References

Jullien-Flores V.,et al.J. Biol. Chem. 270:22473-22477(1995).
Awasthi S.,et al.Biochemistry 39:9327-9334(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ikeda M.,et al.J. Biol. Chem. 273:814-821(1998).
Rosse C.,et al.J. Biol. Chem. 278:30597-30604(2003).

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$ 395.00
Cat# ALS17206
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