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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLC7A8 / LAT2 Antibody (clone 4H10)   

SLC7A8 / LAT2 Antibody (clone 4H10)

Mouse Monoclonal Antibody

     
  • IHC-P - SLC7A8 / LAT2 Antibody (clone 4H10) ALS17207
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - SLC7A8 / LAT2 Antibody (clone 4H10) ALS17207
    Anti-SLC7A8 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently...
  • IF - SLC7A8 / LAT2 Antibody (clone 4H10) ALS17207
    Immunofluorescent staining of HepG2 cells using anti-SLC7A8 mouse monoclonal antibody.
  • FC - SLC7A8 / LAT2 Antibody (clone 4H10) ALS17207
    Flow cytometry of Jurkat cells, using anti-SLC7A8 antibody, (Red) compared to a nonspecific...
  • FC - SLC7A8 / LAT2 Antibody (clone 4H10) ALS17207
    Flow cytometry of Jurkat cells, using anti-SLC7A8 antibody (Red), compared to a nonspecific...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, IP, Flo
Primary Accession Q9UHI5
Other Accession 23428
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4H10
Calculated MW 58382 Da
Dilution Flo (1:100), IF (1:50 - 1:100), IHC-P (10 µg/ml),
Additional Information
Gene ID 23428
Other Names SLC7A8, HLAT2, LPI-PC1, Integral membrane protein E16H
Target/Specificity Human SLC7A8
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsSLC7A8 / LAT2 Antibody (clone 4H10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC7A8
Synonyms LAT2
Function Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
Cellular Location Cytoplasm. Basolateral cell membrane; Multi- pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi
Tissue Location Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2.
Research Areas
Citations (0)

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Background

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.

References

Pineda M.,et al.J. Biol. Chem. 274:19738-19744(1999).
Rossier G.,et al.J. Biol. Chem. 274:34948-34954(1999).
Borsani G.,et al.Nat. Genet. 21:297-301(1999).
Park S.Y.,et al.Arch. Pharm. Res. 28:421-432(2005).
Li W.B.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS17207
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