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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AOX1 / Aldehyde Oxidase Antibody (aa521-570)   

AOX1 / Aldehyde Oxidase Antibody (aa521-570)

Rabbit Polyclonal Antibody

     
  • IHC-P - AOX1 / Aldehyde Oxidase Antibody (aa521-570) ALS17212
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - AOX1 / Aldehyde Oxidase Antibody (aa521-570) ALS17212
    Western blot of extracts from HeLa cells, using AOX1 Antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q06278
Other Accession 316
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 147918 Da
Dilution ELISA (1:40000), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 316
Other Names AOX1, AO, Aldehyde oxidase 1, AOH1, Aldehyde oxidase
Target/Specificity AOX1 Antibody detects endogenous levels of total AOX1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsAOX1 / Aldehyde Oxidase Antibody (aa521-570) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AOX1
Synonyms AO
Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
Cellular Location Cytoplasm
Tissue Location Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.

References

Wright R.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993).
Wright R.M.,et al.Redox Rep. 3:135-144(1997).
Ichida K.,et al.Biochem. Biophys. Res. Commun. 282:1194-1200(2001).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS17212
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