|Application ||WB, IHC-P, E|
|Calculated MW||70384 Da|
|Dilution||IHC-P (3 - 10 µg/ml),|
|Reconstitution & Storage||PBS, pH 7.4. Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GGA1 Antibody (clone 3F11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Boman A.L.,et al.Mol. Biol. Cell 11:1241-1255(2000).
Dell'Angelica E.C.,et al.J. Cell Biol. 149:81-94(2000).
Hirst J.,et al.J. Cell Biol. 149:67-80(2000).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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