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GGA1 Antibody (clone 3F11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UJY5 |
| Other Accession | 26088 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG |
| Clone Names | 3F11 |
| Calculated MW | 70384 Da |
| Dilution | IHC-P (3 - 10 µg/ml), |
| Gene ID | 26088 |
|---|---|
| Other Names | GGA1 |
| Target/Specificity | Human GGA1 |
| Reconstitution & Storage | PBS, pH 7.4. Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GGA1 Antibody (clone 3F11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GGA1 |
|---|---|
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein Early endosome membrane; Peripheral membrane protein |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
References
Boman A.L.,et al.Mol. Biol. Cell 11:1241-1255(2000).
Dell'Angelica E.C.,et al.J. Cell Biol. 149:81-94(2000).
Hirst J.,et al.J. Cell Biol. 149:67-80(2000).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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