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RPS6KB2 / S6K2 Antibody (clone 4B11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9UBS0 |
| Other Accession | 6199 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a,k |
| Clone Names | 4B11 |
| Calculated MW | 53455 Da |
| Dilution | IF (10 µg/ml), IHC-P (10 µg/ml), |
| Gene ID | 6199 |
|---|---|
| Other Names | RPS6KB2, KLS, p70 S6K-beta, p70-beta-1, p70-beta-2, p70S6Kb, p70 ribosomal S6 kinase beta, p70(S6K)-beta, p70-beta, S6K-beta, S6K-beta-2, S6K-beta2, SRK, p70-S6K 2, S6 kinase-related kinase, p70 S6 kinase beta, p70 S6KB, p70S6K2, S6 kinase 2, S6K2, STK14B |
| Target/Specificity | Human RPS6KB2 / S6K2 |
| Reconstitution & Storage | PBS, pH 7.4. Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RPS6KB2 / S6K2 Antibody (clone 4B11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RPS6KB2 |
|---|---|
| Synonyms | STK14B |
| Function | Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). |
| Cellular Location | Cytoplasm. Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates specifically ribosomal protein S6.
References
Gout I.,et al.J. Biol. Chem. 273:30061-30064(1998).
Saitoh M.,et al.Biochem. Biophys. Res. Commun. 253:470-476(1998).
Lee-Fruman K.K.,et al.Oncogene 18:5108-5114(1999).
Koh H.J.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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