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ZFHX3 / ATBF1 Antibody

Rabbit Polyclonal Antibody

  • IHC - ZFHX3 / ATBF1 Antibody ALS17231
    A: anti-ATBF1;B:anti-β-Tubulin;C:Merge
  • IHC-P - ZFHX3 / ATBF1 Antibody ALS17231
    Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC-P - ZFHX3 / ATBF1 Antibody ALS17231
    Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • ICC - ZFHX3 / ATBF1 Antibody ALS17231
  • WB - ZFHX3 / ATBF1 Antibody ALS17231
    western blotting
  • IP - ZFHX3 / ATBF1 Antibody ALS17231
    ip sample :retinoic acid induced neuronal differentiated p19 cells lysates
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15911
Other Accession 463
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 404419 Da
Dilution ICC (1:500), IF (1:500), IHC-P (1:100), WB (1:2000),
Additional Information
Gene ID 463
Other Names ZFHX3, AT motif-binding factor, Zinc finger homeobox 3, ZNF927, ZFH-3, Zinc finger homeobox protein 3, AT motif-binding factor 1, ATBF1, ATBT
Target/Specificity human ZFHX3 / ATBF1
Reconstitution & Storage PBS, pH 7.2, 50% glycerol. Store at -20°C.
PrecautionsZFHX3 / ATBF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFHX3
Synonyms ATBF1
Function Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD- dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down- regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).
Cellular Location Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body
Tissue Location Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Expression is higher in ER-positive breast tumors than ER-negative breast tumors (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer.


Miura Y.,et al.J. Biol. Chem. 270:26840-26848(1995).
Morinaga T.,et al.Mol. Cell. Biol. 11:6041-6049(1991).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Loftus B.J.,et al.Genomics 60:295-308(1999).

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$ 425.00
Cat# ALS17231
Availability: 5 days
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