|Application ||WB, IHC-P, E|
|Calculated MW||24003 Da|
|Dilution||ELISA (1:500 - 1:1000), IHC-P (15 µg/ml), WB (1:500 - 1:1000),|
|Other Names||FGF19, Fibroblast growth factor 19, FGF-19|
|Target/Specificity||Recognizes human FGF-19. Detects a band of ~25kDa by Western blot.|
|Reconstitution & Storage||PBS, pH 7.4, no preservatives. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||FGF19 Antibody (clone FG98-6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.|
|Tissue Location||Expressed in fetal brain, cartilage, retina, and adult gall bladder.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Nishimura T.,et al.Biochim. Biophys. Acta 1444:148-151(1999).
Xie M.-H.,et al.Cytokine 11:729-735(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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