|Application ||WB, IHC-P, E|
|Calculated MW||63544 Da|
|Dilution||ELISA (1:2000 - 1:5000), IHC-P (10 µg/ml), WB (1:2000 - 1:5000),|
|Other Names||GRN, Acrogranin, CLN11, Epithelin precursor, GEP, gp88, Granulin, Granulin-epithelin, Granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, Progranulin|
|Target/Specificity||Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.|
|Reconstitution & Storage||PBS, pH 7.4, no preservatives. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||GRN / Granulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.|
|Tissue Location||In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Bhandari V.,et al.Biochem. Biophys. Res. Commun. 188:57-63(1992).
Plowman G.D.,et al.J. Biol. Chem. 267:13073-13078(1992).
Bhandari V.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992).
Lu R.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.