|Application ||WB, IHC-P, E|
|Calculated MW||63544 Da|
|Dilution||ELISA (1:2000 - 1:5000), IHC-P (10 µg/ml), WB (1:2000 - 1:5000),|
|Other Names||GRN, Acrogranin, CLN11, Epithelin precursor, GEP, gp88, Granulin, Granulin-epithelin, Granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, Progranulin|
|Target/Specificity||Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.|
|Reconstitution & Storage||PBS, pH 7.4, no preservatives. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||GRN / Granulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.|
|Tissue Location||In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney|
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Provided below are standard protocols that you may find useful for product applications.
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Bhandari V.,et al.Biochem. Biophys. Res. Commun. 188:57-63(1992).
Plowman G.D.,et al.J. Biol. Chem. 267:13073-13078(1992).
Bhandari V.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992).
Lu R.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
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