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PSMB5 Antibody

Rabbit Polyclonal Antibody

     
  • IHC-P - PSMB5 Antibody ALS17241
    Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - PSMB5 Antibody ALS17241
    Immunofluorescence analysis of U2OS cell using PSMB5 antibody. Blue: DAPI for nuclear staining.
  • WB - PSMB5 Antibody ALS17241
    Western blot analysis of extracts of various cell lines, using PSMB5 antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P28074
Other Accession 5693
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 28480 Da
Dilution IF (1:50 - 1:200), IHC-P (2.5 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 5693
Other Names PSMB5, Proteasome chain 6, Proteasome subunit MB1, Proteasome subunit X, Proteasome catalytic subunit 3, Macropain epsilon chain, MB1, LMPX, Proteasome beta 5 subunit, Proteasome epsilon chain, Proteasome subunit beta type-5
Target/Specificity Human PSMB5 / MB1.
Reconstitution & Storage PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
PrecautionsPSMB5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMB5
Synonyms LMPX, MB1, X
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).
Cellular Location Cytoplasm. Nucleus.
Volume 50 µl
Research Areas
Citations (0)

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Background

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).

References

Abdulla S.,et al.Immunogenetics 44:254-258(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS17241
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