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PRG2 / Proteoglycan 2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P13727 |
| Other Accession | 5553 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 25206 Da |
| Dilution | IHC-P (5 µg/ml), WB (1:500 - 1:2000), |
| Gene ID | 5553 |
|---|---|
| Other Names | PRG2, BMPG, Bone marrow proteoglycan, Bone-marrow proteoglycan, Eosinophil major basic protein, MBP1, Natural killer cell activator, Proteoglycan 2, Proteoglycan 2 preproprotein |
| Target/Specificity | Human PRG2 / Proteoglycan 2 |
| Reconstitution & Storage | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles. |
| Precautions | PRG2 / Proteoglycan 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRG2 |
|---|---|
| Synonyms | MBP |
| Function | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
| Cellular Location | [Bone marrow proteoglycan]: Secreted. Note=The proform is secreted |
| Tissue Location | Detected in plasma and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in placenta (at protein level) (PubMed:32337544). High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
References
Barker R.L.,et al.J. Exp. Med. 168:1493-1498(1988).
Barker R.L.,et al.Submitted (OCT-1989) to the EMBL/GenBank/DDBJ databases.
Barker R.L.,et al.Gene 86:285-289(1990).
McGrogan M.,et al.J. Exp. Med. 168:2295-2308(1988).
Yoshimatsu K.,et al.Mol. Immunol. 29:537-546(1992).
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