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GC / Vitamin D-Binding Protein Antibody

Rabbit Polyclonal Antibody

     
  • IHC-P - GC / Vitamin D-Binding Protein Antibody ALS17246
    Human Testis, Leydig Cells: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • WB - GC / Vitamin D-Binding Protein Antibody ALS17246
    Western blot analysis of extracts of various cell lines, using GC antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P02774
Other Accession 2638
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 52918 Da
Dilution IHC-P (10 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 2638
Other Names GC, Gc-globulin, HDBP, Group-specific component, GRD3, VDB, VDBG, VDBP, Vitamin D-binding protein
Target/Specificity Human GC / Vitamin D-Binding Protein
Reconstitution & Storage PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
PrecautionsGC / Vitamin D-Binding Protein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GC
Function Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Cellular Location Secreted.
Tissue Location Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.

References

Cooke N.E.,et al.J. Clin. Invest. 76:2420-2424(1985).
Yang F.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:7994-7998(1985).
Braun A.,et al.Biochim. Biophys. Acta 1216:385-394(1993).
Witke W.F.,et al.Genomics 16:751-754(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# ALS17246
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