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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   COPS2 / TRIP15 / ALIEN Antibody   

COPS2 / TRIP15 / ALIEN Antibody

Rabbit Polyclonal Antibody

     
  • IHC-P - COPS2 / TRIP15 / ALIEN Antibody ALS17250
    Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - COPS2 / TRIP15 / ALIEN Antibody ALS17250
    Immunofluorescence blot of U20S cell using COPS2 antibody.
  • WB - COPS2 / TRIP15 / ALIEN Antibody ALS17250
    Western blot analysis of extracts of various cell lines, using COPS2 antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P61201
Other Accession 9318
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 51597 Da
Dilution IF (1:50 - 1:100), IHC-P (5 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 9318
Other Names COPS2, Alien homolog, ALIEN, SGN2, TRIP15, TR-interacting protein 15, Signalosome subunit 2, TRIP-15
Target/Specificity Human COPS2 / TRIP15 / ALIEN.
Reconstitution & Storage PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
PrecautionsCOPS2 / TRIP15 / ALIEN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COPS2
Synonyms CSN2, TRIP15
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Cellular Location Cytoplasm. Nucleus
Volume 50 µl
Research Areas
Citations (0)

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Background

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

References

Dumdey R.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Peng Y.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Lee J.W.,et al.Mol. Endocrinol. 9:243-254(1995).

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$ 395.00
Cat# ALS17250
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