B7-H1 / PD-L1 / CD274 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P |
---|---|
Primary Accession | Q9NZQ7 |
Other Accession | 29126 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 33275 Da |
Dilution | IHC-P (5 - 10 µg/ml), WB (1:500 - 1:2000), |
Gene ID | 29126 |
---|---|
Other Names | CD274, B7-H, B7 homolog 1, B7-H1, B7H1, CD274 molecule, CD274 antigen, PDCD1 ligand 1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed death ligand 1 |
Target/Specificity | Human B7-H1 / PD-L1 / CD274 |
Reconstitution & Storage | PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Precautions | B7-H1 / PD-L1 / CD274 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD274 |
---|---|
Synonyms | B7H1, PDCD1L1, PDCD1LG1, PDL1 |
Function | Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. |
Cellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |

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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
References
Dong H.,et al.Nat. Med. 5:1365-1369(1999).
Freeman G.J.,et al.J. Exp. Med. 192:1027-1034(2000).
He X.-H.,et al.Acta Pharmacol. Sin. 26:462-468(2005).
Chi X.-Y.,et al.Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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