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ABCG8 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9H221 |
| Other Accession | 64241 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75679 Da |
| Dilution | IHC-P (5 µg/ml), WB (1:500 - 1:2000), |
| Gene ID | 64241 |
|---|---|
| Other Names | ABCG8, Sterolin-2, STSL, GBD4, Sterolin 2 |
| Target/Specificity | Human ABCG8 |
| Reconstitution & Storage | PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | ABCG8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCG8 (HGNC:13887) |
|---|---|
| Function | ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359). Low expression levels in the small intestine and colon (PubMed:11099417). Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
References
Berge K.E.,et al.Science 290:1771-1775(2000).
Lu K.,et al.Am. J. Hum. Genet. 69:278-290(2001).
Hillier L.W.,et al.Nature 434:724-731(2005).
Schmitz G.,et al.J. Lipid Res. 42:1513-1520(2001).
Hubacek J.A.,et al.Hum. Mutat. 18:359-360(2001).
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