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Anti-RELN / Reelin Antibody

Rabbit Anti Human Polyclonal Antibody

  • IHC-P - Anti-RELN / Reelin Antibody  ALS17266
    Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78509
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 388388 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 5649
Alias Symbol RELN
Other Names RELN, LIS2, PRO1598, Reelin, RL
Target/Specificity Human RELN / Reelin
Reconstitution & Storage PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAnti-RELN / Reelin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver.
Research Areas
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$ 395.00
Cat# ALS17266
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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