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Anti-XPC Antibody

Rabbit Anti Human Polyclonal Antibody

  • IHC-P - Anti-XPC Antibody  ALS17270
    Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01831
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 105953 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 7508
Alias Symbol XPC
Other Names XPC, RAD4, XPCC, p125, XP3
Target/Specificity Human XPC
Reconstitution & Storage PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAnti-XPC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XPC
Synonyms XPCC
Function Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.
Cellular Location Nucleus. Cytoplasm. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions
Research Areas
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$ 395.00
Cat# ALS17270
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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