|Application ||WB, IHC-P, E|
|Calculated MW||33186 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB|
|Other Names||ASGR1, ASGPR1, ASGPR, ASGPR 1, Asialoglycoprotein receptor 1, Hepatic lectin H1, HL-1, ASGP-R 1, CLEC4H1|
|Target/Specificity||Human ASGR1 / ASGPR.|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Anti-ASGR1 / ASGPR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.|
|Cellular Location||Isoform H1a: Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed exclusively in hepatic parenchymal cells|
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