|Application ||WB, IHC-P, E|
|Calculated MW||150419 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||COL17A1, Alpha 1 type XVII collagen, BA16H23.2, BP180, Bullous pemphigoid antigen 2, BPA-2, BPAG2, Collagen alpha-1(XVII) chain, Collagen, type XVII, alpha 1, Lad-1|
|Target/Specificity||Human COL17A1 / Collagen XVII.|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Anti-COL17A1 / Collagen XVII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.|
|Cellular Location||Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome 97 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane Note=Localized in the lamina lucida beneath the hemidesmosomes|
|Tissue Location||Detected in skin (PubMed:8618013). In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level) (PubMed:25676728). Stratified squamous epithelia Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.|
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