|Application ||WB, IHC-P, E|
|Calculated MW||41432 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||SKAP1, Pp55, SKAP55, SKAP-55, SCAP1|
|Target/Specificity||Human SKAP1 / SCAP1|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Anti-SKAP1 / SCAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.|
|Cellular Location||Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane|
|Tissue Location||Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis Present in T-cells (at protein level)|
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