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Anti-LRRC8A / LRRC8 Antibody (N-Terminus)

Rabbit Anti Human Polyclonal Antibody

  • IHC-P - Anti-LRRC8A / LRRC8 Antibody (N-Terminus)  ALS17304
    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IWT6
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 94199 Da
Dilution ELISA, IHC-P (2.5 - 5 µg/ml), WB (1 - 2 µg/ml)
Additional Information
Gene ID 56262
Alias Symbol LRRC8A
Other Names LRRC8A, AGM5, LRRC8, KIAA1437
Target/Specificity LRRC8A antibody is human, mouse and rat reactive.
Reconstitution & Storage PBS, 0.02% sodium azide. Store at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze thaw cycles.
PrecautionsAnti-LRRC8A / LRRC8 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1437, LRRC8, SWELL1
Function Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
Cellular Location Cell membrane; Multi- pass membrane protein
Tissue Location Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells Expressed on T-cells as well as on B-lineage cells
Research Areas
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$ 395.00
Cat# ALS17304
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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