|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||94199 Da|
|Dilution||ELISA, IHC-P (2.5 - 5 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||LRRC8A, AGM5, LRRC8, KIAA1437|
|Target/Specificity||LRRC8A antibody is human, mouse and rat reactive.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Store at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze thaw cycles.|
|Precautions||Anti-LRRC8A / LRRC8 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1437, LRRC8, SWELL1|
|Function||Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells Expressed on T-cells as well as on B-lineage cells|
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