|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||25218 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||VTI1A, SNARE Vti1a-beta protein, VTI1RP2, MVti1, Vti1-rp2|
|Target/Specificity||VTI1a antibody is human, mouse and rat reactive. At least two isoforms of VTI1a are known to exist; this antibody will detect both isoforms. VTI1a antibody is predicted to not cross-react with VTI1b.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Store at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze thaw cycles.|
|Precautions||Anti-VTI1A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.|
|Cellular Location||Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein|
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