|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||99279 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||DIS3L2, DIS3-like exonuclease 2, PRLMNS, FAM6A|
|Target/Specificity||DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist; this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Store at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze thaw cycles.|
|Precautions||Anti-DIS3L2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.|
|Cellular Location||Cytoplasm. Cytoplasm, P-body|
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