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Anti-DIS3L2 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8IYB7 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 99279 Da |
| Dilution | ELISA, IHC-P (10 µg/ml), WB |
| Gene ID | 129563 |
|---|---|
| Alias Symbol | DIS3L2 |
| Other Names | DIS3L2, DIS3-like exonuclease 2, PRLMNS, FAM6A |
| Target/Specificity | DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist; this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Store at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze thaw cycles. |
| Precautions | Anti-DIS3L2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DIS3L2 {ECO:0000255|HAMAP-Rule:MF_03045} |
|---|---|
| Synonyms | FAM6A |
| Function | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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