|Calculated MW||30778 Da|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI|
|Target/Specificity||Specific for ApoA1, No cross reaction to Apo AII or Apo B|
|Reconstitution & Storage||15mM Potassium Phosphate, 0.85% Sodium Chloride, pH 7.5, 0.1% NaN3 Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||Anti-APOA1 / Apolipoprotein A 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.|
|Tissue Location||Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.|
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